Alkaline Phosphatase - download pdf or read online

By Robert B. McComb

ISBN-10: 1461329701

ISBN-13: 9781461329701

ISBN-10: 1461329728

ISBN-13: 9781461329725

There should be doubtless that alkaline phosphatase is likely one of the such a lot greatly in­ vestigated of all enzymes. This has resulted from the ubiquity of its distribution, and from the convenience and sensitivity with which its job will be measured. regrettably, those wide-ranging yet frequently superficial experimental stories were up by means of extensive and systematic investigations in just a couple of constrained parts of the biochemistry and chemical pathology of alkaline phosphatase. the outcome has been the buildup of a systematic literature of intimidating proportions, and the inevitable rediscovery of already­ recognized proof concerning the enzyme. Scientists are taught early of their careers that, within the phrases of Sir John Herschel, "Hasty generalization is the bane of technological know-how. " however, moments arrive in all spheres of medical task whilst generalization turns into crucial, to codify and to choose between the mass of knowledge already collected, and to supply beginning issues for brand spanking new advancements and new traces of research. this is often very true in a box comparable to alkaline phosphatase learn, during which very actual hazards exist that the seeds of basic figuring out may be misplaced amidst an unexamined harvest of empirical observations. The heritage of the examine of alkaline phosphatase offers a number of circumstances while worthwhile generalizations have emerged. sometimes, the conclusions drawn at the foundation of accessible facts have been flawed; extra usually, they've got stood the try out of additional experimentation, and continuously, they've got supplied new insights into the character and correct­ ties of this enzyme.

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Additional info for Alkaline Phosphatase

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American Men of Science, A Biographical Directory, The Science Press, New York, 1933. 63. Kay, H. , The phosphatases of mammalian tissues, Biochem. , 22, 855, 1928. 64. , Uber die Nierenphosphatase. I. Mitteilung zur Kenntnis der Phosphatasen,z. Physiol. , 232, 165, 1935. 65. , Uber eine einfache Methode zur Darstellung hochaktiver Phosphatasepraparate aus tierischem Material, Z. Physiol. , 232,189,1935. 66. , Zur Kenntnis der alkalischen Damphosphatase, Z. Physiol. , 309, 87, 1957. 67. Morton, R.

Meranze, D. , Blood phosphatase as an aid in the differential diagnosis of jaundice, Am. I. Med. , 192, 526, 1936. 175. Giordano, A. , and Prestrud, M. , The serum phosphatase in the differential diagnosis of obstructive jaundice, Am. I. Clin. , 9,226,1939. 176. Gutman, A. , and Hanger, F. , Differential diagnosis of jaundice by combined serum phosphatase determinations and cephalin flocculation test, Med. Clin. , 25,837, 1941. 177. McLagan, N. , Laboratory tests in the diagnosis of liver disease: A report on three procedures, Br.

Alkaline phosphatase of milk. II. Purification of the enzyme, Biochem. , 55, 795,1953. 73. Morton, R. , The lipoprotein particles in cow's milk, Biochem. , 57,231, 1954. 74. Morton, R. , Some properties of alkaline phosphatase of cow's milk and calf intestinal mucosa, Biochem. , 60, 573,1955. 75. Morton, R. , The substrate specificity and inhibition of alkaline phosphatases of cow's milk and calf intestinal mucosa, Biochem. , 61,232,1955. 76. Morton, R. , The kinetics of hydrolysis of phenyl phosphate by alkaline phosphatases, Bio· chem.

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