Read e-book online Aging at the Molecular Level PDF

By Nicolle Sitte, Thomas von Zglinicki (auth.), Thomas von Zglinicki (eds.)

ISBN-10: 9048164826

ISBN-13: 9789048164820

ISBN-10: 9401706670

ISBN-13: 9789401706674

During the final forty years, the examine of the organic foundation of getting older has stepped forward significantly, and it has now develop into an self sustaining and first rate box of research and study. the fundamental reason behind getting older is molecular harm that slowly overwhelms mobile and organismic safeguard, fix and upkeep structures. lately, a wealth of hugely refined examine has remodeled this concept from a reputable speculation not just to an enormous conception, yet basically to authorized wisdom. getting older on the Molecular point examines the main parts during this transformation.
Bringing jointly contributions from a global group of authors, this quantity could be of curiosity to graduates and postgraduates within the fields of medication and nursing, researchers of alternative features of biogerontology and people within the pharmaceutical, cosmeceutical, nutraceutical and health-care industry.

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Furthermore, another glycosylase for repair of 8-oxoG has recently been discovered, NEILl, that appears 22 ERLING SEEBERG to represent a backup repair activity in these animals [10]. This enzyme may be upregulated in the mutant cells, especially in younger animals [Eide, Seeberg and Klungland, unpublished]. Similarly, two different back up DNA glycosylases for removal of thymine glycols have been detected in mice mutants ofNTHLl [37]. One of these appears to be NEILl, which has activities both against oxidized purines and pyrimidines [10, 37-40].

65: 135-42. 24 ERLING SEEBERG 19. Masson M, Niedergang C, Schreiber V, Muller S, Menissier-de Murcia J, de Murcia G (1998). XRCCl is specifically associated with poly(ADP-ribose) polymerase and negatively regulates its activity following DNA damage. Mol Cell Bioi. 18: 3563-71. 20. Caldecott KW, McKeown CK, Tucker JD, Ljungquist S, Thompson LH (1994). An interaction between the mammalian DNA repair protein XRCCl and DNA ligase III. Mol Cell Bioi. 14: 68-76. 21. Wilson SH (1998). Mammalian base excision repair and DNA polymerase beta.

Effect of spin-trapping compound N-tert-butyl-cxphenylnitrone on protein oxidation and life span. Arch Biochem Biophys. 324: 249-54. 46. Sohal RS, Agarwal S, Candas M, Forster MJ, Lal H (1994). Effect of age and caloric restriction of DNA oxidative damage in different tissues of C57BL/ 6 mice. Mech Ageing Dev. 76: 215-24. 47. Masoro EJ (2000). Caloric restriction and aging: an update. Exp Gerontal. 35: 299-305. 48. Orr WC, Sohal RS (1994). Extension of life span by overexpression of superoxide dismutase and catalase in Drosophila melanogaster.

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Aging at the Molecular Level by Nicolle Sitte, Thomas von Zglinicki (auth.), Thomas von Zglinicki (eds.)


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